Compounds

US8846948B2 · kind B2 · utility

Assignee

• Boehringer Ingelheim International GmbH · DE

Inventors

• Klaus Rudolf · Warthausen, DE
• Daniel Bischoff · Grand Rapids, US
• Georg Dahmann · Biberach an der Riß, DE
• Matthias Grauert · Ingelheim am Rhein, DE
• Raimund Kuelzer · Mittelbiberach, DE

Key dates

• Filing date: Dec 7, 2012
• Grant date: Sep 30, 2014
• Expiry date: Dec 7, 2032

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D473/34
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

This invention relates to compounds of formula Itheir use as positive allosteric modulators of mGlu5 receptor activity, pharmaceutical compositions containing the same, and methods of using the same as agents for treatment and/or prevention of neurological and psychiatric disorders associated with glutamate dysfunction such as schizophrenia or cognitive decline such as dementia or cognitive impairment. A, B, Ar, R1, R2, R3, R3a have meanings given in the description.