Method and device for producing microparticles or nanoparticles

US8852644B2 · kind B2 · utility

Assignee

• Instillo GmbH · DE

Inventors

• Bernd Baumstuemmler · Saarlouis, DE
• Bernd Penth · Lebach, DE
• Felix Penth · Lebach, DE
• Akif Emre Tuereli · Saarlouis, DE

Key dates

• Filing date: Mar 21, 2011
• Grant date: Oct 7, 2014
• Expiry date: Mar 21, 2031

Classification

• Technology area (CPC Y): Emerging Cross-Sectional Technologies
• CPC primary: Y10T428/2982
• WIPO field: Chemical engineering
• WIPO sector: Chemistry

Abstract

The invention relates to a method for producing microparticles or nanoparticles of water-soluble and water-insoluble substances by controlled precipitation, co-precipitation and self-organization processes in microjet reactors, a solvent, which contains at least one target molecule, and a nonsolvent being mixed as jets that collide with each other in a microjet reactor at defined pressures and flow rates and thereby effect very rapid precipitation, co-precipitation or a chemical reaction, during the course of which microparticles or nanoparticles are formed. In order to create such a method, with which the particle size of the resulting microparticles or nanoparticles can be specifically controlled, it is proposed within the scope of the invention that particle size be controlled by the temperature at which the solvent and nonsolvent collide, the flow rate of the solvent and the nonsolvent and/or the amount of gas, smaller particle sizes being obtained at lower temperatures, at high solvent and nonsolvent flow rates and/or in the complete absence of gas.