Patent · US Active

Sperm-specific cation channel, CatSper1 and uses therefor

US8852860B2 · kind B2 · utility

0Cited by
6References
10Claims
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Key dates

Filing dateMay 30, 2012
Grant dateOct 7, 2014
Priority date—
Expiry dateMay 30, 2032

Classification

  • Technology area (CPC A)Human Necessities
  • CPC primaryA01K2267/03
  • WIPO fieldMeasurement
  • WIPO sectorInstruments

Abstract

Nucleic acid and protein sequences relating to a cation channel which is sperm-specific (CatSper1) are disclosed. The CatSper1 protein is shown to be specifically expressed in sperm and to be necessary for sperm motility. Nucleic acids, vectors, transformed cells, transgenic animals, polypeptides, and antibodies relating to the CatSper1 gene and protein are disclosed. Also provided are methods of in vitro fertilization and contraception, methods of identifying modulators of CatSper1 activity, methods of genotyping subjects with respect to CatSper1, and methods of diagnosing and treating CatSper1-mediated disorders, including infertility.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.