Test for predicting neutralization of asparaginase activity
US8852880B2 · kind B2 · utility
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17Claims
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Key dates
| Filing date | Nov 6, 2009 |
| Grant date | Oct 7, 2014 |
| Priority date | — |
| Expiry date | Nov 6, 2029 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N2800/7028
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Method of in vitro measurement of the presence of factors that are able to neutralize asparaginase activity in a sample of blood, plasma, serum or derived medium that may contain asparaginase neutralizing factors, obtained from a patient, comprising mixing of said sample with asparaginase, incubation of said mixture, then measurement of the residual asparaginase activity in the mixture and determination or quantification of the presence of said neutralizing factors. Method for predicting the efficacy of a treatment with asparaginase.
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