Fibronectin based scaffold domain proteins that bind to myostatin

US8853154B2 · kind B2 · utility

Assignee

• Bristol-Myers Squibb Company · US

Inventors

• Sharon Cload · Cambridge, US
• Linda Engle · Framingham, US
• Dasa Lipovsek · Pepperell, US
• Malavi Madireddi · Plainsboro, US
• Ginger Rakestraw · Cambridge, US
• Joanna Swain · Concord, US
• Wenjun ZHAO · Montgomery, US
• Hui Wei · Princeton Junction, US
• Aaron P. YAMNIUK · Lawrenceville, US
• Vidhyashankar Ramamurthy · Kanchinakote, IN
• Alexander T. Kozhich · Princeton, US
• Martin J. Corbett · Mount Holly, US
• Stanley Krystek · Ringoes, US

Key dates

• Filing date: Sep 12, 2013
• Grant date: Oct 7, 2014
• Expiry date: Sep 12, 2033

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07K2319/31
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present invention relates to fibronectin-based scaffold domain proteins that bind to myostatin. The invention also relates to the use of these proteins in therapeutic applications to treat muscular dystrophy, cachexia, sarcopenia, osteoarthritis, osteoporosis, diabetes, obesity, COPD, chronic kidney disease, heart failure, myocardial infarction, and fibrosis. The invention further relates to cells comprising such proteins, polynucleotides encoding such proteins or fragments thereof, and to vectors comprising the polynucleotides encoding the proteins.