Methods for increasing vascular density and maintaining viability of microvascular endothelial cells using trk receptor ligands
US8853163B2 · kind B2 · utility
Assignees
Inventors
Key dates
| Filing date | May 21, 2010 |
| Grant date | Oct 7, 2014 |
| Priority date | — |
| Expiry date | Jan 19, 2031 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K48/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention relates to methods of inducing or inhibiting the angiogenic process and promoting vessel growth or stabilization in an organ by modulating the trk receptor pathway. The present invention also relates to a method for treating a pathological disorder in a patient which includes administering a trk receptor ligand or an inhibitor or expression or activity of a trk receptor ligand. The present invention also relates to a method of screening for a modulator of angiogenesis, vessel growth, or vessel stabilization. Another aspect of the present invention is a method of diagnosing or monitoring a pathological disorder in a patient which includes determining the presence or amount of a trk receptor ligand or activation of a trk receptor ligand in a biological sample.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.