Synthetic glycolipid and use thereof

US8853173B2 · kind B2 · utility

Assignee

• RIKEN · JP

Inventors

• Takuya Tashiro · Wako, JP
• Kenji Mori · Tokyo, JP
• Masao Shiozaki · Wako, JP
• Masaru Taniguchi · Tokyo, JP
• Hiroshi Watarai · Yokohama, JP

Key dates

• Filing date: Feb 4, 2011
• Grant date: Oct 7, 2014
• Expiry date: May 7, 2031

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61P43/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

A compound represented by the following formula (1):wherein R1 is an aldopyranose residue wherein the 6-hydroxyl group is optionally alkylated, R2 is a C1-26 hydrocarbon group optionally having substituent(s), R3 is a hydrogen atom or a C1-26 hydrocarbon group optionally having substituent(s), R4 is a C1-21 hydrocarbon group optionally having substituent(s), X is an oxygen atom or —CH2—, and Y is —CH2—, —CH(OH)— or —CH═CH—, or a salt thereof is useful for the prophylaxis or treatment of cancer or infection, since it can preferentially induce production of IFN-γ of NKT cells.