Patent · US Active

1-oxyalkyl-2-carboxy-7-nonsubstituted indole derivatives

US8853209B2 · kind B2 · utility

2Cited by

6References

12Claims

0Family size

Assignee

Abb Vie Inc. · US

Inventors

Xiaohong Song · Beijing, CN
Hong Ding · Gurnee, US
Steven W. Elmore · Northbrook, US
Milan Bruncko · Libertyville, US
David J. Madar · Gilbert, US
Andrew J. Souers · Libertyville, US
Cheol-Min Park · Gurnee, US
Zhi-Fu Tao · Vernon Hills, US
Xilu Wang · Grayslake, US
Aaron R. Kunzer · Arlington Heights, US

Key dates

Filing date	Apr 15, 2011
Grant date	Oct 7, 2014
Priority date	—
Expiry date	Nov 7, 2032

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC07D403/04
WIPO fieldPharmaceuticals
WIPO sectorChemistry

Abstract

Compounds of Formula Iwherein A1, B1, C1, D1, E1, F1 and L1 are as defined herein, which inhibit the activity of anti-apoptotic Mcl-1 protein, compositions containing the compounds, and methods of treating diseases involving overexpressed or unregulated Mdl-1 protein, such as leukemia and lymphoma, are disclosed.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.