Patent · US Active

Engineered botulinum neurotoxin C1 with selective substrate specificity

US8853360B2 · kind B2 · utility

0Cited by

1References

5Claims

0Family size

Assignee

Wisconsin Alumni Research Foundation · US

Inventors

Meyer B. Jackson · Madison, US
Dongsheng Wang · Sichuan, CN

Key dates

Filing date	Jun 23, 2011
Grant date	Oct 7, 2014
Priority date	—
Expiry date	May 14, 2032

Classification

Technology area (CPC G)Physics
CPC primaryG01N2333/33
WIPO fieldBiotechnology
WIPO sectorChemistry

Abstract

An isolated polypeptide comprising a botulinum neurotoxin C1 light chain having a modified amino acid sequence relative to the sequence of a wild-type botulinum neurotoxin C1 light chain is disclosed. The modified botulinum neurotoxin C1 light chain is capable of selectively cleaving syntaxin protein, but has substantially reduced or no activity against SNAP-25 as compared to wild type botulinum neurotoxin C1 light chain, and is thus useful as a research tool and in medical treatment.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.