Processes for the preparation of morphinane and morphinone compounds
US8853401B2 · kind B2 · utility
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27Claims
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Key dates
| Filing date | Apr 22, 2010 |
| Grant date | Oct 7, 2014 |
| Priority date | — |
| Expiry date | Feb 14, 2031 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D489/04
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
The present application describes processes for the synthesis of morphinane and morphinone compounds, useful as pharmaceutical agents. Also included are novel intermediates useful in the preparation of these compounds. The process comprises quaternization of oripavine to provide a mixture of the R- and S-isomeric (at the nitrogen) quaternary salts. The R-isomer is readily isolated and converted to various N-(R)-morphinane and N-(S)-morphinone compounds. The R-isomer, S-isomer or a mixture of R- and S-isomers may be demethylated and converted to various morphinane and morphinone compounds.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.