Patent · US Active

Process and apparatus for measuring binding events on a microarray of electrodes

US8855955B2 · kind B2 · utility

9Cited by

29References

27Claims

0Family size

Assignee

CustomArray, Inc. · US

Inventors

Kia Peyvan · Seattle, US
Michael Bizak · Kirkland, US
Colin S. Campbell · Pullman, US
Rand W. Lee · Seattle, US

Key dates

Filing date	Sep 29, 2005
Grant date	Oct 7, 2014
Priority date	—
Expiry date	Jun 22, 2027

Classification

Technology area (CPC G)Physics
CPC primaryG01N27/3277
WIPO fieldMeasurement
WIPO sectorInstruments

Abstract

There is disclosed a process and apparatus for reading electrical current of electrodes on a microarray of electrodes. Those electrodes having binding events are detected by a difference in electrical current flow. Enzymes on targets catalyze the conversion of substrate to product, which is detectable by electrochemical reduction at each electrode on the microarray of electrodes. The apparatus has an integration circuit that provides a voltage output that is measured and recorded over time and used to calculate an average current flow. A potentiometer equalizes voltage at electrodes undergoing measurement compared to grounded electrodes.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.