Manufacture of chromatography matrices
US8858800B2 · kind B2 · utility
1Cited by
14References
5Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Aug 30, 2006 |
| Grant date | Oct 14, 2014 |
| Priority date | — |
| Expiry date | Nov 22, 2026 |
Classification
- Technology area (CPC B)Performing Operations; Transporting
- CPC primaryB01J39/19
- WIPO fieldChemical engineering
- WIPO sectorChemistry
Abstract
The present invention relates to a method of manufacturing a chromatography matrix comprising providing a polysaccharide carrier comprising available hydroxyl groups; and reacting said hydroxyl groups with vinyl sulphonate to provide a sulphonate-functionalized (S-functionalized) cation exchanger. The hydroxyl groups of the carrier may be hydroxyls of the agarose polymer; or alternatively they may be provided on extenders such as polyhydroxyfunctional polymers. In one embodiment, the carrier is made of agarose with improved flow pressure properties.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.