Phosphodiesterase 1-targeting tracers and methods
US8858911B2 · kind B2 · utility
20Cited by
1References
6Claims
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Key dates
| Filing date | Oct 7, 2010 |
| Grant date | Oct 14, 2014 |
| Priority date | — |
| Expiry date | Oct 7, 2030 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01T1/2985
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Tracers targeting phosphodiesterase 1 for use in gamma radiation detection-based diagnostic techniques, particularly gamma-emitter labeled tracers for SPECT and positron emitter-labeled compositions for PET are disclosed. Radio-labeled multiple novel scaffolds as PDE1 inhibitors such as substituted pyrazolo-pyrimidin-4-one derivatives, biomarkers for phosphodiesterase 1 [PDE1) in vivo, methods for developing novel therapies for PDE1-implicated conditions such as pulmonary arterial hypertension (PAH), Central Nervous System (CNS) and Cardiovascular (CV) disorders, and methods of detection and treatment are also disclosed.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.