Sperm-specific cation channel, CATSPER3, and uses therefor
US8859197B2 · kind B2 · utility
Assignee
Inventors
Key dates
| Filing date | Jan 30, 2012 |
| Grant date | Oct 14, 2014 |
| Priority date | — |
| Expiry date | Jan 30, 2032 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12Q2600/156
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
Nucleic acid and protein sequences relating to a cation channel which is sperm-specific (CatSper3) are disclosed. The CatSper3 protein is shown to be specifically expressed in sperm. Nucleic acids, vectors, transformed cells, transgenic animals, polypeptides, and antibodies relating to the CatSper3 gene and protein are disclosed. Also provided are methods of in vitro fertilization and contraception, methods of identifying modulators of CatSper3 activity, methods of genotyping subjects with respect to CatSper3, and methods of diagnosing and treating CatSper3-mediated disorders, including infertility. Related business methods are also disclosed.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.