In vitro differentiation of pluripotent stem cells to pancreatic endoderm cells (PEC) and endocrine cells
US8859286B2 · kind B2 · utility
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20Claims
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Key dates
| Filing date | Dec 13, 2013 |
| Grant date | Oct 14, 2014 |
| Priority date | — |
| Expiry date | Dec 13, 2033 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N2533/90
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
A human immature endocrine cell population and methods for making an immature endocrine cell population are provided. Specifically, immature beta cells and methods for production of immature beta cells are described. Immature beta cells co-express INS and NKX6.1 and are uni-potent and thereby develop into mature beta cells when implanted in vivo. The mature beta cells in vivo are capable of producing insulin in response to glucose stimulation.
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