Simultaneous, integrated selection and evolution of antibody/protein performance and expression in production hosts
US8859467B2 · kind B2 · utility
4Cited by
18References
13Claims
0Family size
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Inventor
Key dates
| Filing date | Jul 16, 2010 |
| Grant date | Oct 14, 2014 |
| Priority date | — |
| Expiry date | Jul 16, 2030 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07K2317/52
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
The present disclosure provides methods of integrating therapeutic protein and antibody generation and/or selection, evolution and expression in a eukaryotic host for manufacturing in a single system. Therapeutic proteins, including antibodies, are generated, optimized and manufactured in the same eukaryotic host system. The disclosed system of Comprehensive Integrated Antibody Optimization (CIAO!™) allows for simultaneous evolution of protein performance and expression optimization.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.