Tetrahydronaphthyridine and tetrahydropyrido[4,3-D]pyrimidine compounds and compositions thereof useful for the treatment of inflammatory and respiratory diseases

US8859545B2 · kind B2 · utility

Assignee

• EVOTEC AG · DE

Inventors

• Michael G. Kelly · Thousand Oaks, US
• John Kincaid · Hayward, US
• Carl Kaub · San Jose, US

Key dates

• Filing date: Mar 1, 2010
• Grant date: Oct 14, 2014
• Expiry date: Dec 30, 2030

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61P43/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Tetrahydronaphthyridine and tetrahydropyrido[4,3-d]pyrimidine compounds are disclosed that have formula 1:where A, B, L, N, R1, R3, R4′, Y and Z are as defined herein. The compounds and pharmaceutical compositions thereof are useful for the prevention and treatment of a variety of conditions in mammals including humans, including by way of non-limiting example, pain, inflammation, respiratory conditions, and others.