Patent · US Active

Aryl- and heteroarylcarbonyl derivatives of benzomorphanes and related scaffolds, medicaments containing such compounds and their use

US8859580B2 · kind B2 · utility

0Cited by

27References

9Claims

0Family size

Assignee

Boehringer Ingelheim International GmbH · DE

Inventors

Frank Himmelsbach · Mittelbiberach, DE
Matthias Eckhardt · Hannover, DE
Bradford S. Hamilton · Toronto, CA
Armin Heckel · Biberach an der Riß, DE
Joerg Kley · Mittelbiberach, DE
Thorsten Lehmann-Lintz · Ochsenhausen, DE
Herbert Nar · Ochsenhausen, DE
Stefan Peters · Biberach an der Riß, DE
Annette Schuler-Metz · Ulm, DE
Matthias Zentgraf · Biberach, DE

Key dates

Filing date	Nov 14, 2008
Grant date	Oct 14, 2014
Priority date	—
Expiry date	Jun 5, 2030

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC07D498/08
WIPO fieldOrganic fine chemistry
WIPO sectorChemistry

Abstract

The present invention relates to compounds defined by formula Iwherein the groups R1 to R3, X, m, n and o are defined as in claim 1, possessing valuable pharmacological activity. Particularly the compounds are inhibitors of 11β-hydroxysteroid dehydrogenase (HSD) 1 and thus are suitable for treatment and prevention of diseases which can be influenced by inhibition of this enzyme, such as metabolic diseases, in particular diabetes type 2, obesity and dyslipidemia.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.