TRPV1 antagonists

US8859584B2 · kind B2 · utility

Assignee

• Abb Vie Inc. · US

Inventors

• Kevin R. Woller · Antioch, US
• Gregory A. Gfesser · Lindenhurst, US
• Huaqing Liu · Buffalo Grove, US
• Jerome F. Daanen · Racine, US
• Eric A. Voight · Pleasant Prairie, US
• Irene Drizin · Wadsworth, US
• Anurupa Shrestha · Gurnee, US
• Kathleen H. Mortell · Chicago, US
• Philip R. Kym · Libertyville, US
• Michael E. Kort · Lake Bluff, US
• Arthur Gomtsyan · Vernon Hills, US

Key dates

• Filing date: Dec 17, 2012
• Grant date: Oct 14, 2014
• Expiry date: Dec 17, 2032

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D491/052
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Disclosed herein are compounds of formula (I):or pharmaceutically acceptable salts thereof, wherein X1, L, Rx, Ry, Rz, A, m, n, p, q, s, and positions a and b are as defined in the specification. Compositions comprising such compounds and methods for treating conditions and disorders using such compounds and compositions are also disclosed.