(2E)-3-phenyl-N-[2,2,2-Trifluoro-1-[[8-quinolineamino)thiomethyl]amino]ethyl]-2-acrylamide and pharmaceutical uses thereof

US8859587B2 · kind B2 · utility

Assignee

• CHINESE PLA GENERAL HOSPITAL · CN

Inventors

• Kunlun He · Baofeng County, CN
• Song Li · Beijing, CN
• Lili Wang · Beijing, CN
• Xin Li · Shanghai, CN
• Wu Zhong · Beijing, CN
• Guoliang Hu · Nanchang, CN
• Jie Wang · Lake Bluff, US
• Ruijin Li · Beijing, CN
• Chunlei Liu · Shanghai, CN
• Junhai Xiao · Beijing, CN
• Long Long · Beijing, CN
• Wei Li · Lexington, US
• Hua Chen · Beijing, CN

Key dates

• Filing date: May 14, 2010
• Grant date: Oct 14, 2014
• Expiry date: May 14, 2030

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61P9/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present invention relates to an acrylamide compound of Formula I, or an isomer, pharmaceutically acceptable salt and solvate thereof, to a composition comprising the compound or an isomer, pharmaceutically acceptable salt and solvate thereof, and a pharmaceutically acceptable carrier, excipient or diluent, and to a use of the compound or the composition for prophylaxis and/or treatment of a disease or disorder associated with cardiomyocyte apoptosis.