Polymorphs of N-(6-(4-chlorophenoxy)hexyl)-N′-cyano-N″-(4-pyridyl)guanidine, and preparation thereof and use thereof

US8859594B2 · kind B2 · utility

Assignees

• Tianjin Hemay Bio-Tech Co., Ltd. · CN
• Tianjin Michele Sci-Tech Development Co., Ltd. · CN

Inventors

• Hesheng Zhang · Tianjin, CN
• Xin Chen · Tangxia, CN

Key dates

• Filing date: Oct 25, 2011
• Grant date: Oct 14, 2014
• Expiry date: Oct 25, 2031

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61P43/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Disclosed are a polymorphs I-VI of N-(6-(4-chlorophenoxy)hexyl)-N′-cyano-N″-(4-pyridyl)guanidine or of a solvate thereof, a preparation method thereof, and a use thereof as a biological active ingredient. The polymorphs are useful in treatment of cancers, and diseases or disorders caused by abnormal cell proliferation.