Compounds, compositions and methods for reducing toxicity and treating or preventing diseases

US8859615B2 · kind B2 · utility

Inventors

• Samuel J. Danishefsky · New Haven, US
• Ting-Chao Chou · Paramus, US
• Xiaoguang Lei · Yongchang Subdistrict, CN
• Heedong Yun · Tenafly, US
• Fay Ng · New York, US
• John Hartung · Evanston, US
• Dalibor Sames · New York, US

Key dates

• Filing date: Aug 27, 2009
• Grant date: Oct 14, 2014
• Expiry date: Oct 8, 2030

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07C2601/14
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present invention provides compounds of Formula (I), compositions comprising an effective amount of a compound of Formula (I), optionally with chemotherapeutic drugs such as a tubulin-binding drug, and methods of their use for reducing the toxicity of cytotoxic agents, treating or preventing cancer or a neuropathic disorder, inducing a chemoprotective phase II enzyme, DNA, or protein synthesis, enhancing the immune system, treating inflammation, improving and enhancing general health or well-being, and methods for making compounds of Formula (I).