Bioactive hydrogel

US8859706B2 · kind B2 · utility

Assignee

• Zeta SCIENCE GmbH · DE

Inventors

• Carsten Werner · Kassel, DE
• Uwe Freudenberg · Dresden, DE
• Dorit Meinhold · Dresden, DE
• Marie-Francoise Gouzy · Allschwil, CH
• Petra Welzel · Dresden, DE

Key dates

• Filing date: Nov 28, 2008
• Grant date: Oct 14, 2014
• Expiry date: May 25, 2030

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C08J2371/02
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The invention relates to a bioactive hydrogel as a hybrid material of heparin and star-branched polyethylene glycol with functionalized end groups, wherein the heparin is bound directly by reaction of the carboxyl groups activated with 1-ethyl-3-(3-dimethylaminopropyl) carbodiimides/N-hydroxysulfosuccinimide (EDC/s-NHS) with the terminal amino groups of the polyethylene glycol covalently by amide bonds.