Signature for the diagnosis of cancer aggressiveness and genetic instability
US8865408B2 · kind B2 · utility
Assignees
Inventors
Key dates
| Filing date | May 18, 2011 |
| Grant date | Oct 21, 2014 |
| Priority date | — |
| Expiry date | May 27, 2032 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12Q2600/158
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
The present invention relates to a method for diagnosing aggressiveness and/or genetic instability of a cancer in a patient from a cancer sample of the patient. The method includes measuring in vitro the expression level of the POLQ gene and the expression level of a control gene in the patient cancer sample, calculating an expression level ratio of the expression level of POLQ to the expression of the control gene in the patient cancer sample, comparing the expression level ratio to a corresponding threshold value, and diagnosing cancer aggressiveness and genetic instability if the POLQ expression level ratio is superior to a corresponding threshold value. Dedicated microarrays and kits are also described, as well as a method of selecting a suitable treatment.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.