Methods and compositions for risk stratification
US8865420B2 · kind B2 · utility
2Cited by
57References
32Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | May 22, 2008 |
| Grant date | Oct 21, 2014 |
| Priority date | — |
| Expiry date | Oct 31, 2029 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY10T436/25
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
The present invention provides an approach for the simultaneous determination of the activation states of a plurality of proteins in single cells. This approach permits the rapid detection of heterogeneity in a complex cell population based on activation states, and the identification of cellular subsets that exhibit correlated changes in activation within the cell population. Moreover, this approach allows the correlation of cellular activities or properties. In addition, the use of potentiators of cellular activation allows for characterization of such pathways and cell populations.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.