Methods and compositions for inhibition of the transitional endoplasmic reticulum ATPase

US8865708B2 · kind B2 · utility

Assignees

• CALIFORNIA INSTITUTE OF TECHNOLOGY · US
• University of Kansas · US
• Cleave Biosciences, Inc. · US

Inventors

• Raymond Deshaies · Pasadena, US
• Tsui-Fen Chou · Pasadena, US
• Frank J. Schoenen · Lawrence, US
• Kelin Li · Lawrence, US
• Kevin Frankowski · Lawrence, US
• Jeffrey Aube · Lawrence, US
• Samuel Gerritz · Guilford, US
• Han-Jie Zhou · Foster City, US

Key dates

• Filing date: May 6, 2011
• Grant date: Oct 21, 2014
• Expiry date: May 6, 2031

Classification

• Technology area (CPC G): Physics
• CPC primary: G01N2500/02
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Compounds of Formulas I-XLIII are identified as direct inhibitors of p97 ATPase or of the degradation of a p97-dependent ubiquitin-proteasome system (UPS) substrate. Methods and compositions are disclosed for inhibiting p97 ATPase and the degradation of a p97-dependent UPS substrate, and for identifying inhibitors thereof.