Substituted heterocycles and their use as allosteric modulators of nicotinic and GABAA receptors
US8865719B2 · kind B2 · utility
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5Claims
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Key dates
| Filing date | Mar 9, 2010 |
| Grant date | Oct 21, 2014 |
| Priority date | — |
| Expiry date | Mar 9, 2030 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61P43/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention is related to heterocycles represented by a compound of Formula I that are novel allosteric modulators of α7 nAChRs and/or GABAA receptors. The invention also discloses the treatment of disorders that are responsive to enhancement of acetylcholine action on α7 nAChRs and negative allosteric modulation of GABAA receptors in a mammal by administering an effective amount of a compound of Formula I.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.