Anti-biofilm agents

US8865909B2 · kind B2 · utility

Assignees

• YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM LTD. · IL
• HADASIT MEDICAL RESEARCH SERVICES AND DEVELOPMENT LTD. · IL

Inventors

• Morris Srebnik · Mevaseret Tsiyon, IL
• Itzhack Polacheck · Jerusalem, IL
• Doron Steinberg · Jerusalem, IL
• Adel Jabbour · Nazareth Ilit, IL
• Edward Sionov · Holon, IL

Key dates

• Filing date: Nov 19, 2009
• Grant date: Oct 21, 2014
• Expiry date: Jan 23, 2030

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C08F220/56
• WIPO field: Macromolecular chemistry, polymers
• WIPO sector: Chemistry

Abstract

Novel agents exhibiting anti-biofilm formation activity while being non-cytotoxic are provided, as well as methods of using the same, either per se or conjugated to a polymer, for preventing and/or reducing the formation of microbial biofilms and/or for disrupting microbial biofilms. The novel agents described herein include thiazolidine-2,4-diones (TZDs), pyrrolidine-2,5-diones (PYDs), imidazolidine-2,4-diones or oxazolidine-2,4-diones, substituted by an alkyl having 7-20 carbon atoms in its backbone chain.