Fluorescent probes for detection of copper

US8865914B2 · kind B2 · utility

Assignee

• The Regents of the University of California · US

Inventors

• Christopher J. Chang · Berkeley, US
• Genevieve Van de Bittner · Campbell, US
• Tasuku Hirayama · Gifu, JP
• Jefferson Chan · Berkeley, US

Key dates

• Filing date: Mar 14, 2013
• Grant date: Oct 21, 2014
• Expiry date: Mar 14, 2033

Classification

• Technology area (CPC G): Physics
• CPC primary: G01N33/84
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The invention provides fluorescent sensors for the selective detection of a metal such as copper. The sensors may be considered to be derivatives of cyanine, fluorescein, rhodamine, rhodol, Tokyo green, or BODIPY. The sensors find particular use in detecting copper in cells and living animals.