Active protease-resistant antibody FC mutants
US8871204B2 · kind B2 · utility
8Cited by
4References
31Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Jul 23, 2012 |
| Grant date | Oct 28, 2014 |
| Priority date | — |
| Expiry date | Jul 29, 2032 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07K2317/94
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
The present invention relates to modified Fc-containing molecules including modified antibodies characterized by increased resistance to host and pathogen-derived proteases, ability to interact with FcγR receptors except with FcγRI, and lack of induction of IL-10 secretion by macrophages, and methods of using and making them.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.