Amyloid-beta polypeptide vaccine

US8871212B2 · kind B2 · utility

Assignee

• H. LUNDBECK A/S · DK

Inventors

• Peter Birk Rasmussen · Paseo Los Muchachos, DK
• Martin Roland Jensen · Paseo Los Muchachos, DK
• Klaus Gregorius Nielsen · Copenhagen, DK
• Peter Koefoed · Hørsholm, DK
• Florence Dal Degan · Avenue Madeleine, DK

Key dates

• Filing date: Dec 19, 2008
• Grant date: Oct 28, 2014
• Expiry date: Mar 10, 2031

Classification

• Technology area (CPC Y): Emerging Cross-Sectional Technologies
• CPC primary: Y02A50/30
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Disclosed are novel methods and compositions for combating diseases characterized by deposition of amyloid. The methods generally rely on immunization against amyloid precursor protein (APP) or beta amyloid (Aβ). Immunization is preferably effected by administration of analogs of autologous APP or Aβ, said analogs being capable of inducing antibody production against the autologous amyloidogenic polypeptides. Especially preferred as an immunogen is autologous Aβ which has been modified by introduction of one single or a few foreign, immunodominant and promiscuous T-cell epitopes. Such methods and means include methods for the preparation of analogs and pharmaceutical formulations, as well as nucleic acid fragments, vectors, transformed cells, polypeptides and pharmaceutical formulations.