Biomarkers and methods for determining disease progression in nonalcoholic steatohepatitis (NASH)
US8871454B2 · kind B2 · utility
0Cited by
0References
47Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Jan 26, 2011 |
| Grant date | Oct 28, 2014 |
| Priority date | — |
| Expiry date | Nov 22, 2032 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY10T436/200833
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
Diets high in saturated fat and fructose have been implicated in the development of obesity and nonalcoholic steatohepatitis (NASH) in humans. Provided herein are biomarkers, methods, and animal models useful for the investigation and non-invasive detection of NASH, including a non-invasive biomarker that could be used to establish disease severity, follow progression, and evaluate response to treatment in clinical trials for this increasingly prevalent disease.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.