Compositions and methods for treating AIDS or cancer by inhibiting the secretion of microparticles

US8871708B2 · kind B2 · utility

Inventors

• Vincent C. Bond · Stone Mountain, US
• Michael Powell · Shrewsbury, US
• Ming Bo Huang · Atlanta, US
• Syed Ali · Merang, MY
• Andrea D. Raymond · Coconut Creek Park, US
• Martin Neville Shelton · Mountlake Terrace, US
• Francois Jean Villinger · Decatur, US

Key dates

• Filing date: Aug 30, 2013
• Grant date: Oct 28, 2014
• Expiry date: Aug 30, 2033

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C12N2740/16322
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Novel peptides that inhibit the release of microparticles from cells are disclosed. The peptide contains at least one VGFPV motif at the N-terminal and has a length of 10-100 amino acids. Also disclosed is polynucleotide encoding the peptide, expression vectors carrying the polynucleotide, and methods for treating AIDS and tumors using the novel peptides.