Monomethylvaline compounds having phenylalanine carboxy modifications at the C-terminus
US8871720B2 · kind B2 · utility
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64References
11Claims
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Key dates
| Filing date | Jul 7, 2006 |
| Grant date | Oct 28, 2014 |
| Priority date | — |
| Expiry date | Nov 10, 2029 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY02A50/30
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Auristatin peptide analogs of MeVal-Val-Dil-Dap-Phe (MMAF) having a carboxylic acid equivalent at the C-terminal phenylalanine were prepared and attached to ligands through various linkers, including maleimidocaproyl-val-cit-PAB. The resulting ligand drug conjugates were active in vitro and in vivo.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.