Chemical modification of short small hairpin RNAs for inhibition of gene expression
US8871730B2 · kind B2 · utility
2Cited by
5References
26Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Jul 13, 2010 |
| Grant date | Oct 28, 2014 |
| Priority date | — |
| Expiry date | Dec 20, 2030 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N2320/53
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Aspects of the present invention include the production and use of chemically modified RNAi agents (e.g., shRNAs) in gene silencing applications. The chemically modified RNAi agents disclosed herein have reduced immunostimulatory activity, increased serum stability, or both, as compared to a corresponding RNAi agent not having the chemical modification. Compositions containing chemically modified RNAi agents according to aspects of the present invention (including pharmaceutical compositions) and kits containing the same are also provided.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.