6-and 7-amino isoquinoline compounds and methods for making and using the same

US8871757B2 · kind B2 · utility

Assignee

• Aerie Pharmaceuticals, Inc. · US

Inventors

• Mitchell A. deLong · Chapel Hill, US
• Jill Marie Sturdivant · Chapel Hill, US
• Geoffrey Richard Heintzelman · Annandale, US
• Susan M. Royalty · Cary, US

Key dates

• Filing date: Feb 12, 2010
• Grant date: Oct 28, 2014
• Expiry date: Jun 10, 2030

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D409/12
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

6- and 7-amino isoquinoline compounds are provided that influence, inhibit or reduce the action of a kinase. Pharmaceutical compositions including therapeutically effective amounts of the 6- and 7-aminoisoquinoline compounds and pharmaceutically acceptable carriers are also provided. Various methods using the compounds and/or compositions to affect disease states or conditions such as cancer, obesity and glaucoma are also provided.