[1,2,4]triazolo[3,4-C][1,4]oxazines as P2X7 modulators

US8871760B2 · kind B2 · utility

Assignee

• Roche Palo Alto LLC · US

Inventors

• Christine E. Brotherton-Pleiss · Sunnyvale, US
• Ralph New Harris, III · Redwood City, US
• Bradley E. Loe · Santa Cruz, US
• Francisco Javier Lopez-Tapia · Mahwah, US
• Pankaj D. Rege · Basel, CH
• David Bruce Repke · Palo Alto, US
• Russell Stephen Stabler · Mountain View, US
• Keith A. M. Walker · Los Altos Hills, US

Key dates

• Filing date: Sep 15, 2010
• Grant date: Oct 28, 2014
• Expiry date: Sep 15, 2030

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D513/04
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Compounds of the formula I:or pharmaceutically acceptable salts thereof, wherein X, Y, R1, R2, and R3 are as defined herein. Also disclosed are methods of making the compounds and using the compounds for treatment of diseases associated with the P2X7 purinergic receptor.