Phenylpyrimidone compounds, the pharmaceutical compositions, preparation methods and uses thereof

US8871777B2 · kind B2 · utility

Assignees

• TOPHARMAN SHANGHAI CO., LTD. · CN
• SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES · CN
• TOPHARMAN SHANDONG CO., LTD. · CN

Inventors

• Zheng Liu · Beacon Falls, US
• Jianfeng Li · Qingdao, CN
• Xiaojun Yang · Shanghai, CN
• Zhen Wang · Shanghai, CN
• Jinfeng Zhang · Shanghai, CN
• Yi Zhu · Shanghai, CN
• Guanghui Tian · 安丰镇, CN
• Qing Jin · Shanghai, CN
• Jingkang Shen · Shanghai, CN
• Weiliang Zhu · Shanghai, CN
• Hualiang Jiang · Shanghai, CN
• Jingshan Shen · Shanghai, CN

Key dates

• Filing date: Dec 10, 2009
• Grant date: Oct 28, 2014
• Expiry date: Jul 10, 2030

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07H15/26
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present invention relates to a class of phenylpyrimidone compounds, the pharmaceutical composition, the preparation method and the use thereof. More specifically, the present invention relates to a type of phenylpyrimidone compounds of the following formula I, the pharmaceutically acceptable salts or solvates thereof and to the pharmaceutical composition as well as the preparation method of the compounds. The compounds of formula I according to the present invention can effectively inhibit type V phosphodiesterase (PDE5), and thus can be used for the treatment of various vascular disorders, such as male erectile dysfunction, pulmonary hypertension and the like.