Patent · US Active

Engineered heterodimeric protein domains

US8871912B2 · kind B2 · utility

53Cited by

8References

5Claims

0Family size

Assignee

Merck Patent GmbH · DE

Inventors

Jonathan Davis · Waltham, US
James S. Huston · Newton, US

Key dates

Filing date	Mar 23, 2007
Grant date	Oct 28, 2014
Priority date	—
Expiry date	Jan 7, 2032

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC07K2319/30
WIPO fieldBiotechnology
WIPO sectorChemistry

Abstract

The present invention provides an engineered multidomain protein including at least two nonidentical engineered domains, each of which contains a protein-protein interaction interface containing amino acid sequence segments derived from two or more existing homologous parent domains, thereby conferring on the engineered domains assembly specificities distinct from assembly specificities of the parent domains. In particular, the engineered domains form heterodimers with one another preferentially over forming homodimers. Methods of designing and using the engineered proteins are also included.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.