Tailored raman spectrocopic probes for ultrasensitive and highly multiplexed assays
US8873038B2 · kind B2 · utility
Assignee
Inventors
Key dates
| Filing date | Oct 20, 2011 |
| Grant date | Oct 28, 2014 |
| Priority date | — |
| Expiry date | Mar 25, 2032 |
Classification
- Technology area (CPC B)Performing Operations; Transporting
- CPC primaryB82Y40/00
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
Embodiments of nanostructured, multilayered metal-dielectric particles suitable for use as Raman spectroscopic probes are disclosed, as well as methods of designing, making and using such multilayered nanoparticles, and kits including the multilayered nanoparticles. The multilayered nanoparticles include alternating metal and dielectric layers and an outer dielectric shell. One or more of the dielectric layers may include a plurality of reporter molecules. Embodiments of the multilayered nanoparticles are suitable for detecting target analytes in a sample. Some embodiments of the multilayered nanoparticles are suitable for use in multiplexed assays, including assays for multiple target analytes having differing concentrations.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.