Determination of spatial proximity between features of interest in biological tissue
US8873827B2 · kind B2 · utility
Assignee
Inventors
Key dates
| Filing date | Jun 29, 2012 |
| Grant date | Oct 28, 2014 |
| Priority date | — |
| Expiry date | Apr 27, 2033 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG06T2207/30024
- WIPO fieldComputer technology
- WIPO sectorElectrical engineering
Abstract
Exemplary embodiments enable determination of spatial proximity between two or more features in biological tissue. An exemplary method includes identifying a morphological feature in an image of the biological tissue based on expression levels of a first biomarker indicative of the morphological feature, and receiving a result of a segmentation analysis performed on the image of the biological tissue identifying a set of morphological units in the image external to the morphological feature. An exemplary method includes determining an expression level of a second biomarker corresponding to each unit in the set of morphological units in the image of the biological tissue, and determining a spatial distance between the morphological feature and each unit in the set of morphological units. An exemplary method further includes automatically determining a relationship between expression levels of the second biomarker and corresponding spatial distance from the morphological feature of the set of morphological units.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.