Intestinal brake inducing intraluminal therapeutic substance eluting devices and methods

US8876761B2 · kind B2 · utility

Assignee

• Ethicon Endo-Surgery, Inc. · US

Inventors

• Thomas Albrecht · Beilngries, DE
• Jeffrey L. Aldridge · Lebanon, US
• Sean P. Conlon · Loveland, US
• Michael S. Cropper · Edgewood, US
• Denzel Z. Herrera-Davis · Cincinnati, US
• Daniel F. Dlugos, Jr. · Sharonville, US
• Jason L. Harris · Lebanon, US
• Christopher J. Hess · Cincinnati, US
• Prasanna Malaviya · Huangpu District, CN
• Glenda C. Marsh · São Paulo, BR
• Mark S. Ortiz · Milford, US
• Mark D. Overmyer · Cincinnati, US
• Alessandro Pastorelli · Roma, IT
• Galen C. Robertson · Apex, US
• Frederick E. Shelton, IV · Hillsboro, US
• Michael J. Stokes · Cincinnati, US
• James W. Voegele · Cincinnati, US
• Lauren S. Weaner · Cincinnati, US
• William B. Weisenburgh, II · Maineville, US
• Christopher W. Widenhouse · Clarksville, US
• Tamara S. Vetro Widenhouse · Clarksville, US
• James A. Woodard, Jr. · Mason, US
• David C. Yates · Morrow, US
• Mark S. Zeiner · Milford, US
• Andrew M. Zwolinski · Cincinnati, US

Key dates

• Filing date: May 10, 2011
• Grant date: Nov 4, 2014
• Expiry date: Sep 26, 2032

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61N1/37205
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Methods and devices create an intestinal braking effect, are non-invasive or minimally invasive, and may be reversible. These methods and devices are accomplished via stabilized implantable systems and ingestible pills. In one embodiment, a method of producing satiety comprising the steps of accessing a gastrointestinal tract of a patient and implanting an intraintestinal therapeutic substance eluting implant. The implant is capable of eluting a satiety inducing substance selected from at least one of a nutrient, a specific satiety inducing bio-active substance, pancreatic polypeptides, free fatty acids, cholecystokinin, amino acids, glutamine, lipids, linoleic acid, or a combination thereof, from the implant into the gastrointestinal tract.