N-alkoxyamide conjugates as imaging agents

US8877157B2 · kind B2 · utility

Assignee

• Lantheus Medical Imaging, Inc. · US

Inventors

• Richard R. Cesati · Pepperell, US
• Thomas D. Harris · Salem, US
• Simon P. Robinson · Stow, US
• Richard J. Looby · Reading, US
• Edward H. Cheesman · Lunenburg, US
• Padmaja Yalamanchili · Princeton, US
• David S. Casebier · Carlisle, US

Key dates

• Filing date: Jul 8, 2010
• Grant date: Nov 4, 2014
• Expiry date: Mar 10, 2031

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D257/02
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present disclosure is directed to compounds, diagnostic agents, and related methods. In some cases, methods for treating patients are provided. More specifically, the disclosure provides compounds, diagnostic agents, and kits for detecting and/or imaging and/or monitoring elastin rich tissues. In addition, the disclosure provides methods of detecting and/or imaging and/or monitoring the presence of coronary plaque, carotid plaque, iliac/femoral plaque, aortic plaque, renal artery plaque, plaque of any arterial vessel, aneurism, vasculitis, other diseases of the arterial wall, and/or damage or structural changes in ligaments, uterus, lungs or skin, as indicated by changes in total vessel wall area, internal lumen size, and exterior arterial perimeter.