Patent · US Active

TNF-α binding proteins

US8877194B2 · kind B2 · utility

5Cited by

1References

21Claims

0Family size

Assignee

Abb Vie Inc. · US

Inventors

Chung-Ming Hsieh · Newton, US
Carrie Goodreau · Ludlow, US
Sahana Bose · Marlborough, US
Achim Moeller · Grünstadt, DE
Tariq Ghayur · Holliston, US

Key dates

Filing date	Dec 8, 2011
Grant date	Nov 4, 2014
Priority date	—
Expiry date	Dec 8, 2031

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC07K2319/30
WIPO fieldPharmaceuticals
WIPO sectorChemistry

Abstract

TNF-α binding proteins, including chimeric, CDR-grafted, and humanized antibodies that bind TNF-α are provided. Binding proteins have high affinity for TNF-α and neutralize TNF-α activity. A binding protein can be a full-length antibody or a TNF-α-binding portion thereof. Methods of making and methods of using the binding proteins are also described. The TNF-α binding proteins are useful for detecting TNF-α and for inhibiting TNF-α activity, including in a human subject suffering from a disease or disorder in which TNF-α activity is detrimental.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.