Liposomes active in-vivo on neurodegenerative diseases
US8877236B2 · kind B2 · utility
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13Claims
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Key dates
| Filing date | Jun 28, 2012 |
| Grant date | Nov 4, 2014 |
| Priority date | — |
| Expiry date | Jun 28, 2032 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61P25/28
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
New liposomes are described, comprising: (i) phosphatidic acid and/or cardiolipin; (ii) apolipoprotein E (ApoE) or derivatives thereof. The so modified liposomes, administered systemically, obtain a dramatic in-vivo reduction of the amyloid plaque in the central nervous system, allowing an effective treatment of neurodegenerative diseases, in particular Alzheimer's disease.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.