Method for rapidly evaluating performance of short interfering RNA with novel chemical modifications
US8877439B2 · kind B2 · utility
19Cited by
0References
18Claims
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Assignee
Inventors
Key dates
| Filing date | Dec 9, 2010 |
| Grant date | Nov 4, 2014 |
| Priority date | — |
| Expiry date | Dec 9, 2030 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N2320/51
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
It is an object of the instant invention to provide a method for the rapid evaluation of novel sugar modifications to be used in siRNA synthesis including the rapid evaluation of chemical modification patterns within the siRNA to effectuate increased stability and ultimately increased efficacy of a siRNA therapeutic. It is a further object of the instant invention to provide novel nucleosides useful for siRNA therapy.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.