Ultrathin parylene-C semipermeable membranes for biomedical applications
US8877489B2 · kind B2 · utility
Assignees
Inventors
Key dates
| Filing date | Jan 20, 2012 |
| Grant date | Nov 4, 2014 |
| Priority date | — |
| Expiry date | Feb 23, 2032 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N2539/00
- WIPO fieldMedical technology
- WIPO sectorInstruments
Abstract
Thin parylene C membranes having smooth front sides and ultrathin regions (e.g., 0.01 μm to 5 μm thick) interspersed with thicker regions are disclosed. The back sides of the membranes can be rough compared with the smooth front sides. The membranes can be used in vitro to grow monolayers of cells in a laboratory or in vivo as surgically implantable growth layers, such as to replace the Bruch's membrane in the eye. The thin regions of parylene are semipermeable to allow for proteins in serum to pass through, and the thick regions give mechanical support for handling by a surgeon. The smooth front side allows for monolayer cell growth, and the rough back side helps prevents cells from attaching there.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.