Patent · US Active

Targeting microRNAs for metabolic disorders

US8877730B2 · kind B2 · utility

7Cited by
1References
21Claims
0Family size

Assignee

Inventors

Key dates

Filing dateOct 23, 2013
Grant dateNov 4, 2014
Priority date—
Expiry dateOct 23, 2033

Classification

  • Technology area (CPC C)Chemistry; Metallurgy
  • CPC primaryC12N2320/35
  • WIPO fieldPharmaceuticals
  • WIPO sectorChemistry

Abstract

Provided herein are methods and compositions for the treatment of metabolic disorders. Also provided herein are methods and compositions for the reduction of blood glucose level, the reduction of gluceoneogenesis, the improvement of insulin resistance and the reduction of plasma cholesterol level. In certain embodiments, the methods comprise inhibiting the activity of miR-103. In certain embodiments, the methods comprise inhibiting the activity of miR-107. In certain embodiments, the activity of both miR-103 and miR-107 is inhibited. In certain embodiments, such methods comprise administering a compound comprising an oligonucleotide targeted to a microRNA.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.