CCR2 receptor antagonists, method for producing the same, and use thereof as medicaments

US8877745B2 · kind B2 · utility

Assignee

• Boehringer Ingelheim International GmbH · DE

Inventors

• Heiner Ebel · Biberach an der Riß, DE
• Sara Frattini · Castelleone, IT
• Riccardo Giovannini · Verona, IT
• Christoph Hoenke · Ingelheim am Rhein, DE
• Rocco Mazzaferro · San Giuliano Milanese, IT
• Stefan Scheuerer · Warthausen, DE

Key dates

• Filing date: May 10, 2011
• Grant date: Nov 4, 2014
• Expiry date: Sep 7, 2031

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D495/04
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present invention relates to novel antagonists for CCR2 (CC chemokine receptor 2) of formula (I) wherein HET is a group selected from among formulas (IIa) (IIb) (IIc) (IId) and their use for providing medicaments for treating conditions and diseases, especially pulmonary diseases like asthma and COPD and pain diseases.