Spiro-oxindole MDM2 antagonists

US8877796B2 · kind B2 · utility

Assignee

• THE REGENTS OF THE UNIVERSITY OF MICHIGAN · US

Inventors

• Shaomeng Wang · Saline, US
• Shanghai Yu · Shanghai, CN
• Wei-Chuan Sun · Menlo Park, US
• Sanjeev Kumar · Ann Arbor, US
• Duxin Sun · Ann Arbor, US
• Peng Zou · Ann Arbor, US
• Donna McEachern · Ann Arbor, US
• Yujun Zhao · Ann Arbor, US

Key dates

• Filing date: Jul 17, 2013
• Grant date: Nov 4, 2014
• Expiry date: Jul 17, 2033

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07F9/6561
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Provided herein are compounds, compositions, and methods in the field of medicinal chemistry. The compounds and compositions provided herein relate to spiro-oxindoles which function as antagonists of the interaction between p53 and MDM2, and their use as therapeutics for the treatment of cancer and other diseases.